We built an AI that audits CRO budgets line by line and flags overbilling, inflated change orders, and unnecessary line items. Most sponsors don't realize they're overpaying until it's too late — Prova catches it immediately and gives you the exact language to push back.
Meet Ava — your AI coworker who runs the financial side of your trial, from CRO contracts to invoices to change orders. She connects cost to execution so nothing slips through. Ava doesn't wait for you to ask — she tells you when something is wrong. Start with budget intelligence; expand into full trial operations.
Got a change order on your desk? Run it through the Council — $250Meet your trial team
Ava runs your trial finances. Eli helps you decide what to do next.
Two layers: an always-on financial operator plus a simulation engine for enrollment, retention, and site economics.
Owns the money path: CRO contracts, structured budgets, invoices, and change orders. She ties dollars to what actually happened on the ground so you can negotiate with receipts, not vibes.
Stress-tests enrollment pace, dropout risk, and site mix — so you can see trade-offs between sticker price per patient and total trial clock before you lock the grid.
Meet Ava
“I'm Ava, your AI coworker that owns the financial side of your trial — from CRO contracts to invoices to change orders. I drive an efficient study on time and on budget: I watch every dollar, flag unnecessary change requests, catch overbilling, and give you the data to push back on your CRO. I'm always on, and I never miss a line item.”
Ava connects cost to execution across vendors, timelines, and documents — but her authority starts with financial control: benchmarks, variance, and negotiation-ready outputs so you never overpay.
The problem
Change orders are often 40%+ inflated. Without an independent model, sponsors accept at face value.
Invoice-to-contract reconciliation is manual, error-prone, and inconsistent. Discrepancies slip through every cycle.
Without your own cost model, you have no data to negotiate. You rely on CRO assumptions — and overpay.
Where the money leaks
Most studies don't lose seven figures on one mistake — they lose it across dozens of preventable ones. Prova makes those leaks visible, early, in dollars.
Line items are often priced above benchmark — monitoring, startup, PM overhead.
Example: visits at $3,200 vs $2,200 benchmark × 200 visits → $200K overpayment risk.
Prova impact: typically $150K–$500K identified per trial from audit alone.
Mid-study COs arrive with thin justification; teams accept because they lack an independent baseline.
Example: $2.6M in change orders where 30–40% is negotiable inflation.
Prova impact: $500K–$1M+ in defensible counter-positions and language.
“Cheap” sites that enroll slowly extend the trial clock — overhead and opportunity cost dominate.
Example: 3 extra months at ~$400K/month all-in burn → $1.2M you never put in the per-patient spreadsheet.
Prova impact: $1M–$2M+ by modeling price vs speed before you commit.
Plans assume compliance and retention that real patients don't deliver — then you pay for rescue enrollment.
Example: 20% worse dropout than modeled → extra enrollment wave and monitoring → $500K–$2M in unplanned work.
Prova impact: catch the drift early; quantify the budget hit before it hits the CRO invoice.
Illustrative ranges based on typical mid-to-late-stage study economics; your trial may differ. The point is directionally true across portfolios: small misses compound.
Ava catches these before they become real costs.
We save you millions, predictably — by making trial spend legible, benchmarked, and negotiable.
What Prova does
Upload or paste your CRO budget. Ava flags above-benchmark pricing, unnecessary items, and generates counter-offer language for every flagged line.
“Site startup at $62K exceeds the $25K–$45K benchmark. Here's how to push back.”
Tell Ava about your trial and she asks the right questions to build a 12-section budget model. Edit line items through chat — just say “update monitoring to 15 visits at $3,200 each” and she updates it live.
“I've updated your monitoring costs: 15 visits x $3,200 = $48,000. Your total budget is now $2.4M.”
Track actual invoices against your budget in real-time. Ava generates proactive alerts when categories trend over budget, flags suspicious variances, and suggests cost containment strategies before overruns happen.
“Monitoring costs are 18% over budget. At current burn rate, you'll exceed by $140K. Here's a containment plan.”
CRO sends an $800K change order? Ava analyzes the justification, compares to your baseline, and tells you exactly what's inflated.
“This change order is 40% inflated based on site activity. Counter at $480K.”
Ava compares invoices against your contract and trial activity. If you were charged for 10 monitoring visits but only 6 occurred, she catches it.
“You were invoiced for 10 site visits but only 6 occurred. Dispute: $24,000.”
An expensive AMC might enroll faster and reduce total trial duration — saving more than the per-patient premium. Eli simulates enrollment scenarios across multiple sites, balancing price, speed, and capacity to find the optimal configuration.
“Adding 2 AMC sites increases per-patient cost by 30% but saves 4 months and $2.1M in daily overhead.”
How it works
Upload a CRO budget, or let Ava build one through conversation. She asks the right questions and populates the model for you.
Each item is benchmarked, flagged, and assessed. You see what's fair, what's high, and what's unnecessary.
As invoices come in, track actual vs budgeted spend. Ava alerts you proactively when categories trend over budget.
Get counter-offer amounts, talking points, and savings estimates. Walk into your next CRO call with leverage.
Your AI budget analyst & model builder
Ava builds your budget model through conversation. Ask questions, edit line items, check benchmarks, or build a cost model from scratch. She edits the structured budget in real-time as you talk.
Eli: “The Global strategy costs 25% less despite higher startup costs — faster enrollment saves $1.2M in daily overhead. LATAM sites drive the speed advantage at $12K/patient.”
Site economics engine
A high-cost AMC that enrolls 4 patients/month can reduce total trial duration by months — saving more in daily overhead than the per-patient premium. Eli models these trade-offs across your entire site network.
Beyond budgets
Ava starts as your financial operator — budgets, invoices, change orders, and vendor spend. From there she extends into the rest of trial operations so cost and execution stay in one place.
Models cost, retention, site enrollment dynamics, and price/speed trade-offs
Eli simulates enrollment scenarios across your site network, balancing per-patient cost against enrollment speed. An expensive AMC might save you months of trial overhead — Eli finds the optimal configuration. Plus retention modeling across 15 friction variables per participant.
Owns CRO economics end-to-end; expands into full trial ops from there
Ava watches your budget 24/7, matches it to invoices and activity, and flags drift before it becomes a change order. She builds your cost model through conversation, generates pushback language, and surfaces what to challenge next — without waiting for you to ask.
The market
In two sentences
Prova is an AI system that audits CRO spend and gives sponsors an independent view of what their trial should cost. We help teams catch overbilling, push back on change orders, and save millions per study — with dollar-level examples you can take to your next governance call.
Upload a CRO budget and let Ava audit every line. See where you're overpaying, get counter-offer language, and walk into your next vendor call with data — before another seven figures leak out in change orders and pass-throughs.
No integration required. Results in seconds.